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KMID : 0604520170430020125
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 2 p.125 ~ p.135
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Study on Anti-oxidant and Anti-inflammatory Activity of Eggplant-cheongyeolsodokum
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Yoon Jong-Moon
Kim Dong-In
Lee Ji-Hye
Han So-Jung
Kim Ha-Eun
Kim Hyeon-Jeong
Nam Kyu-Woo
Park Ji-Yeon
Chi Gyeong-Yup
An Bong-Jeun
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Abstract
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The purpose of this study is verification of the anti-oxidant effect and anti-inflammatory effect of Eggplant-cheongyeolsodokum composed of 8 herbs (Solanum melongena L., Lonicera japonica Thunb., Glycyrrhiza uralensis Fisch., Ligusticum chuanxiong Hort., Angelica gigas Nakai., Coptis deltoidea C. Y. Cheng et Hsiao., Gardenia jasminoides J. Ellis., Forsythia suspensa Vahl) to confirm the possibilities as useful cosmetic material. We used the modified prescription of 'cheongyeolsodokum' contained in Korean traditional medical book 'Donguibogam' as composition of Eggplant-cheongyeolsodokum and their proportions. Eggplant-cheongyeolsodokum were extracted with hot water, 70% ethanol and then powdered. To confirm anti-oxidant effect, we investigated radical scavenging ability (DPPH, ABTS+, superoxide), superoxide dismutase (SOD)-like activity, total polyphenolic contents. Also to confirm anti-inflammatory effect, we investigated inhibition effect of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, and Inhibition effect of the expression of inflammatory-related proteins (iNOS, COX-2) by western blot analysis. As a result, Eggplant-cheongyeolsodokum showed good anti-oxidant and anti-inflammation effects, we suggest that it can be used as an active ingredient for cosmetics.
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KEYWORD
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anti-oxidant , anti-inflammatory , RAW264.7 cell , polyphenol , cosmetics
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